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THE BRAIN FROM TOP TO BOTTOM When a nociceptor fibre detects a pain stimulus on the skin or in an internal organ, the pain signal is transmitted to the spinal cord and then on to the brain by neural pathways different from those for the sense of touch.. At each of the synapses along this pain pathway, several neurotransmitters are involved in carrying the nociceptive message. EmiratesSkills Registration - Welcome to ACTVET